International conference and Expo on

Cardiology and Cardiac Surgery

April 04-06, 2016, Dubai, UAE

Scientific Programme(Day 2 : Apr-05-2016)

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Current Research in Cardiology

Session Introduction

Time: 10:30-10:50 AM
Ingolf Schimke
Berlin Cures GmbH, Germany
Title: Aptamers for neutralization of pathogenic autoantibodies directed against g-protein coupled receptors present in patients with cardiomyopathy: steps to a new treatment option

Biography: Ingolf Schimke has completed his Ph.D at the age of 27 years from “Akademie der Wissenschaften” of the German Democratic Republic and postdoctoral studies from “Humbold Universität zu Berlin” Medicine. Until 2014, he was Professor for Clinical Chemistry and Laboratory Medicine at the “Charité – Universitätsklinikum Berlin” and is presently Director of Research & Development at “Berlin Cures GmbH”. He has published more than 100 papers in reputed journals. He is presently the editor-in-chief of Laboratoriums Medizin/Journal of Laboratory Medicine and is serving as an editorial board member of reputed journals.

Abstract: Background/Introduction With the finding of autoantibodies directed against G-protein coupled receptors (GPCR-AABs) in diseased subjects – mainly those suffering from diseases of the cardiovascular system – a new class of autoimmune diseases (agonistic autoantibody disease) has been introduced. While autoantibodies in the classic autoimmune diseases play a role in the destruction of their targets and target tissues, GPCR-AABs are so-called “functional autoantibodies” that agonistically activate their related receptors in a similar way to the physiologic agonists, but without controlling by mechanisms such as, for example, receptor downregulation. Cardiomyopathies such as idiopathic dilated cardiomyopathy (DCM), Chagas’ cardiomyopathy and Peripartum cardiomyopathy present with autoantibodies against G-protein coupled receptors (GPCR-AABs) mainly such directed against the beta1-adrenergic and muscarinic2 receptors which are clearly evidenced as driving the pathogenesis. Aims/Objectives For the treatment of “agonistic autoantibody disease” and in particular DCM, the removal of the GPCR-AABs by immunoadsorption (IA) has been studied with convincing patient benefit. To overcome cost and logistics problems of IA, the application of a recently patented aptamer (single short DNA molecule that bind high-specifically GPCR-AABs) for in vivo neutralization of GPCR-AABs could help. Method/Results The aptamer neutralized in vitro beta1- and M2-AABs prepared from serum of cardiomyopathy patients and demonstrated its in vivo neutralizing potency after aptamer treatment of GPCR-AAB positive animals. Furthermore, the same reduction of beta1-AABs was achieved when patients were either immunoadsorbed or patient serum containing the beta1-AABs was ex vivo treated with the aptamer.


Time: 10:50-11:10 AM
Mojgan gharipour
Isfahan University of Medical Sciences, Iran
Title: Comparision between European and Iranian cut-points of triglyceride/high density lipoprotein cholesterol concentration in prediction of cardiovascular disease outcomes

Biography: Mojgan Gharipour received her Ph.D. in Molecular Epidemiology in Atherosclerosis from Isfahan University of Medical Sciences in 2016 and Masters of Clinical Biochemistry from the same university in 2000.
She works at Cardiovascular Disease Research Institute and is the managing editor of the ARYA Atherosclerosis Journal. Her areas of research include metabolic syndrome, molecular epidemiology of cardiovascular disease and risk factor. She has published more than 70 scientific articles in ISI and PubMed/Medline journals.She won the award of the young investigator in succession by Scientific Meetings of the European Society of Hypertension from 2008 to 2014. She also won the award of the best researcher from the Cardiovascular research Center and Isfahan Governor General several times from 2007 to 2014. She is working on her new project in the pathway of selenoproteins in cardiovascular disease.

Abstract: Background: High triglycerides (TG) and low high density lipoprotein cholesterol (HDL-C) are important cardiovascular risk factors. The prognostic value of the TG/HDL-C ratio, a marker for cardiovascular events is unknown among Iranian so this study aimed to determine the best-cut point of TG/HDL-C in predicting CVD events among Iranian population. Method: Isfahan Cohort Study was a longitudinal population-based study that was conducted on adults aged 35 years or older, living in urban and rural areas of three districts in central part of Iran.. After 10 years of follow-up, 3255 participants were re-evaluated using a standard protocol similar to the baseline. At both measurements, participants underwent medical interview, physical examination, and fasting blood measurements. High risk subjects were defined by the discrimination power of indices was assessed using receiver operating characterist (ROC) analysis and the best cut-point value for each index was derived.


Time: 11:10-11:30 AM
May Faraj
University of Montreal, Canada
Title: HyperapoB, fat tissue dysfunction and risk for type 2 diabetes in humans

Biography: Dr. May Faraj is currently an associate professor, department of nutrition at Montreal University. She also has many roles like an adjunct professor, department of molecular biology at University of Montréal , an invited professor of research, director of laboratory of nutrition, lipoproteins and cardiometabolic disease at Clinical research institute of montréal (IRCM) and a principal investigator at Montreal diabetes research center (MDRC)

Abstract: Background/ Introduction: HyperapoB, or elevated numbers of atherogenic apoB-lipoproteins, is among the most common atherogenic dyslipoproteinemia in patients with type 2 diabetes (T2D). However, epidemiological studies reported that hyperapoB precede the onset of T2D, the mechanisms for which remain unclear. Aims/ Objectives:We aimed to investigate whether increased uptake of apoB-lipoproteinsin fat tissue in subjects with hyperapoB might injure fat tissue and provoke metabolic dysfunction and risk for T2D. Methods:Eighty one normoglycemic obese subjects (45-74 years, BMI ≥ 27 kg/m2, 33 men and 48 post-menopausal women, non-smokers, free of chronic disease) underwent in-depth assessment of glucose and fat metabolism using a high-fat meal, hip fat tissue biopsy and Botnia clamp.

Coffee Break-11:30-11:50 AM

Time: 11:50-12:10 PM
Rami Abu-Fanne
Hadassah Medical Center, Israel
Title: α- defensinsinduce a post-translational modification of ldl that promotes atherosclerosis at normal levels of plasma cholesterol

Biography: Dr. Abu Fanne Rami is currently an Interventional cardiologist at Hillel Yaffe Medical Center, Hadera from 2014 to till present. He had done his Bachelors, Masters and Doctorate from Hebrew university. He worked in Internship at Rambam Health Care Campus, Haifa (2002-2003); Residency in Internal medicine, Hadassah University Hospital, Jerusalem (2003-2007); Cardiology fellowship, Tel Aviv Souraski Medical Center, Tel Aviv (2007-2010); Residency Clinical Biochemistry, Hadassah UniversityHospital, Jerusalem (2010-2014); Invasive Cardiology Fellow. Department of Cardiology, Rambam, Haifa (2012-2013); and as a Senior Cardiologist, Heart failure Unit, Meir Hospital (2012-2013)

Abstract: Background:Almost one-half of patients with atherosclerotic diseases have normal or modest elevations in plasma lipids, whereas animal models are often characterized by marked elevations in plasma cholesterol. Given increasing evidence that inflammation contributes to atherogenesis, we studied the effect of human -defensins (-defs) on atherogenesis in animals with normal or moderately elevated levels of cholesterol. Methods and Results: We studied development of lipid streaks in transgenic mice expressing human -defs in their polymorphonuclear leukocytes (PMNs) (Def+/+) and wildtype mice, which lack PMN--defs. Lesions containing -defs developed in aortic roots of Def+/+ mice fed a regular diet at normal levels of plasma cholesterol. Lesions enlarged and extended when Def+/+ mice were fed a high fat diet that induced moderate elevations in plasma cholesterol. Complexes of α-def/LDL found in the plasma ofDef+/+ mice showed greater vascular deposition than LDL, and Def+/+ mice vasculature showed greater retention of LDL and -def/LDL than WT vessels. Vascular deposition of α-defs was associated with elevated plasma TNFα and increased tissue cathepsin. -defs stimulated TNF-α release from macrophages, which together with α-defs-induced expression of cathepsin by endothelial cells, and increased there permeability to LDL. Treatment with colchicine for two weeks reduced plasma -defs and -def/LDL complexes, while more protracted treatment lowered TNF-α and cathepsin and prevented lesion development.


Time: 12:10-12:30 PM
Salma Mahmoud
King Faisal Specialist Hospital and Research Centre, Saudi Arabia
Title: Bromodomain PHD finger transcription factor (BPTF): a novel regulator of heart failure

Biography: Salma Mahmoud has completed her Ph.D from the Wellcome Trust Centre for Gene Regulation and Expression at the University of Dundee in 2011. Afterthat she joined the Cardiovascular Research Program at King Faisal Specilaist Hopital and Research Center as Scientist working primerly on studying the Epiegetic mechanisms in cardiomyopathies. She is the head of Epigenetic in Heart Failuer Unit in the program. She has more than 15 papers in Peer-reviwed journals such as Nucleic Acid Research, EMBO and the Journal of Pathology.

Abstract: Abstract: Background/Introduction Gene activation or repression relies on the dynamic of chromatin structure. Alteration of chromatin architecture is mediated by two classes of enzymes, the ATP-dependent remodelers and the histone modifications, which allow the conversion of inaccessible (repressive) heterochromatin to (active) accessible euchromatin. These epigenetic processes govern gene expression in all eukaryotic cells. They also recently have emerged as important mechanisms for the regulation of cardiovascular diseases, which remains the major cause of death worldwide. Aims/Objectives There is increasing evidence that chromatin remodeling through post-translational histone modifications regulates cardiovascular diseases. In contrast, the role of ATP-dependent chromatin remodeling in heart diseases remains largely unexplored. On the basis of strong preliminary data that we recently accumulated, we proposed to examine the role of the chromatin-remodeling enzyme BPTF (Bromodomain PHD-finger Transcription Factor) in cardiac hypertrophy and heart failure, which is unknown. Method Comprehensive biochemical and molecular approaches in isolated cardiomyocytes, induced pluripotent stem cells-derived cardiomyocytes (iPSC-CM), model organism and biopsies from human failing hearts are used.


Time: 12:30-12:50 PM
Ahmed R. Ahmed
University Hospital of Essen, Germany
Title: Survival analysis and postoperative complications after ventricular assist device implantation; prognostic value of INTERMACS scale

Biography: Ahmed is a resident physician and a researcher in the department of Thoracic Organ Transplantation at the university hospital of Essen, Germany. He is a graduate of the faculty of Medicine-Alexandria University, 2006, Alexandria, Egypt. He did his Critical Care Medicine residency in Alexandria university hospital. In August 2008 he completed his Master Degree in critical care medicine. He then worked as a specialist in Critical care medicine for 6 years. His most recent study was published in the Transplant International Journal 2015.

Abstract: Background: Ventricular assist devices (VADs) have been proven to be effective in improving survival and quality of life in patients with refractory heart failure. However, outcomes depend on a variety of preoperative parameters. Aim of the study: This study evaluates retrospectively the patients’ profiles, clinical outcome, postoperative complications and mortality in patients who underwent VAD implantation in our center taking into account preoperative Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) levels aiming at anticipation of postoperative complications and optimization of the preoperative strategies. Methods: Between August 2010 and March 2015, 104 patients underwent VAD implantation in our university hospital. INTERMACS profiles were as follow: level 1 in 27 patients, level 2 in 20 patients, level 3 in 27 patients, level 4 in 25 patients, level 5 in 4 patients and level 6 in 1 patients respectively. Patients were divided into 3 groups: Group A included 27 patients at INTERMACS level 1. Group B included 47 patients at INTERMACS level 2/3 and group C included 30 patients at INTERMACS Level 4/5/6. Preoperative clinical, echocardiographic, and hemodynamic and laboratory data were compared between groups as well as the incidence and time of onset of postoperative complications and mortality.


Time: 12:50-13:10 PM
Salma Mahmoud
King Faisal Specialist Hospital and Research Centre, Saudi Arabia
Title: Nuclear CAMKII is a histone H3 kinase that remodels chromatin during cardiac hypertrophy

Biography: Salma Mahmoud has completed her Ph.D from the Wellcome Trust Centre for Gene Regulation and Expression at the University of Dundee in 2011. Afterthat she joined the Cardiovascular Research Program at King Faisal Specilaist Hopital and Research Center as Scientist working primerly on studying the Epiegetic mechanisms in cardiomyopathies. She is the head of Epigenetic in Heart Failuer Unit in the program. She has more than 15 papers in Peer-reviwed journals such as Nucleic Acid Research, EMBO and the Journal of Pathology.

Abstract: Background and purpose: Calcium/calmodulin-dependent protein kinase II (CaMKII) is a ubiquitous serine/threonine kinase implicated in pathological events such as pathological cardiac hypertrophy. In this study we investigated the role of a specific isoform of CaMKII, nuclear CaMKIIδB in chromatin remodeling, to understand its role in transcriptional regulation in cardiac muscle. Methods: Comprehensive experimental approaches were used including chromatin immunoprecipitation assays (ChIP), q-PCR, chromatin remodeling assays, in vitro phosphorylation/transcription assays in the context of chromatin, production of recombinant adenovirus, siRNA technology, fluorescent microscopy and mass spectrometry, performed in primary cardiomyocyte cultures.

Lunch Break-13:10-13:40 PM

Cardiac Therapeutic Agents & Interventional Cardiology

Session Introduction

Time: 13:40-14:00 PM
Hamid Reza Rahimi
Mashhad University of Medical Sciences, Iran
Title: Nano-micelle curcumin (sinacurcumin®) as atherosclerotic plaque stabilizer: A brief report of a randomized clinical trial

Biography: Hamid Reza Rahimi has completed his MD and PhD at the age of 33 years from Mashhad University of medical Sciences in the School of Medicine. He has published more than 20 papers in reputed journals and has been serving as an rewiver of Iranian Red Creasent Medical Journal. He was working on chronic inflammation pathways in coronary artery dieases specialy the effect of Curcumin on plaque stabialazing in CAD.

Abstract: The aim of this study is a clinical trial for evaluation of nano micelle (SinaCurcumin®) administration effects on plaque stabilizing and molecular testing of CD40, CD40L and MMP9inCoronary artery disease patients. Design and Methods: Seventy CAD and diabetic patients (40%≤coronary arteries obstruction<50%) were randomly assigned to SinaCurcumin® (as nano micelle 80 mg/day) or placebo for 3 months in double blind randomized clinical trial. Fast blood glucose, HbA1C, and lipids profile, CD40, CD40L, MMP9 were checked before and after intervention. Data analyses, including parametric and nonparametric tests were undertaken using the SPSS 16 software. A P value < 0.05 was regarded as statistically significant. (RCT registration code: IRCT2013081114330N1).


Time: 14:00-14:20 PM
Jan Raupach
Charles University Hradec Králové, Czech Republic
Title: Endovascular management of acute thromboembolic occlusion of the superior mesenteric artery: a 12-year single centre experience

Biography: Dr. Jan Raupach is currently a faculty of Medicine at Charles University Hradec Králové, Czech Republic. He has completed his Ph.D in the year 2003. He clinically have interest in Stengrafts in the treatment of aortic aneurysms, research on stenting and stentgrafting in transjugular intrahepatic portosystemic shunts, peripheral revascularizations and venous access and interventions. He has also many grants in autologous vein stent-graft, safety and effectiveness of carbon dioxide as an intravascular contrast agent and endovascular repair for the aortic arch. He has many publications in International reputed journals.

Abstract: Background: Acute mesenteric ischemia (AMI) is a life-threatening condition that usually develops after superior mesenteric artery (SMA) occlusion. Early diagnosis and prompt treatment can re-establish mesenteric artery patency and decrease the negative impact of induced ischemic changes. Current advances in endovascular therapy made a mini-invasive approach for restoring patency of the SMA feasible. Aims: To evaluate our 12-year experience with endovascular management of acute mesenteric ischemia (AMI) due to thromboembolic occlusion of the superior mesenteric artery (SMA). Material and Methods: From 2003 to 2014, we analysed the in-hospital mortality of 48 patients with AMI who underwent primary endovascular therapy for SMA occlusion with subsequent exploratory laparotomy. Transcatheter embolus aspiration was used in 37 patients (19 women, 18 men, median age 76 years) with embolic occlusion of the SMA. Adjunctive local thrombolysis (n=2) and stenting (n=2) were also used in this group. During the same period, 11 patients (8 women, 3 men, median age 78 years) were treated with stenting due to acute thrombotic occlusion of the SMA.


Time: 14:20-14:40 PM
Rami Abu-Fanne
Hadassah Medical Center, Israel
Title: Novel insight into the

Biography: Dr. Abu Fanne Rami is currently an Interventional cardiologist at Hillel Yaffe Medical Center, Hadera from 2014 to till present. He had done his Bachelors, Masters and Doctorate from Hebrew university. He worked in Internship at Rambam Health Care Campus, Haifa (2002-2003); Residency in Internal medicine, Hadassah University Hospital, Jerusalem (2003-2007); Cardiology fellowship, Tel Aviv Souraski Medical Center, Tel Aviv (2007-2010); Residency Clinical Biochemistry, Hadassah UniversityHospital, Jerusalem (2010-2014); Invasive Cardiology Fellow. Department of Cardiology, Rambam, Haifa (2012-2013); and as a Senior Cardiologist, Heart failure Unit, Meir Hospital (2012-2013)

Abstract: Background: Geographical miss is a descriptive terminology for a poorly deployed coronary stent and the STLLR trial, which looked specifically this issue, proved the incidence is very high, an astonishing 65% ending with a significantly higher risk for restenosis, target-lesion revascularization (TLR), MI, and stent thrombosis. Yet, the mechanism for this shocking stent plaque dissociation rates, remains to be clarified. Methods: The cyclic movement of the heart and the coronary arteries induces relative axial movement between the artery and a pre-deployed intra-luminal device which may cause mal-positioning of these devices. The exact nature and extent of this phenomenon is not known yet. The Sync-Rx System is an add-on image processing system with unique enhancement and stabilization power. A new feature of this system, the Device Motion Indicator (DMI), can detect the intra-luminal device in the X-Ray image stream and measure its relative axial movement in an enhanced and stabilized background. Using the DMI feature in patients undergoing PCI, we measured the pre-deployment, relative, intra-luminal stent axial movement in the different coronary arteries and their sub-segments.


Time: 14:40-15:00 PM
Janardhana Rao Babburi
Apollo Hospitals, India
Title: Will abandoned pacemaker leads harbor the risk of life threatening arrhythmias? – An interesting case report of abandoned pacemaker lead causing VT and VF and cardiac arrest that necessitated the implantation of ICD.

Biography: With passion towards medical career, Dr. Janardhana Rao Babburi has graduated MBBS from Siddartha Government Medical College, Dr. N.T.R University of Health Sciences, Vijayawada, Andhra Pradesh, India in 2004. He had completed his Post graduation MD degree in Internal Medicine in 2008 from famous Kasturba Medical College, KMC, Manipal, Udupi, Karnataka, India. With passion and interest towards cardiology, Super specaility DM Cardiology degree was obtained from prestigious institute, Sri Ramachandra Medical Center and Research Institute, Porur, Chennai, Tamilnadu, India in 2012. After finishing studies in 2012, He joined in Apollo Heart Institutes, Hyderabad, India and worked as Consultant interventional Cardiologist for 2 years. After working for 2 years in Apollo Heart Institutes, joined in Global Heart Institutes, Global Hospitals, Hyderabad, India and actively involved in treating and managing patients. After working there for a short duration, he moved to Dubai in May 2015 as a specialist Cardiologist, and started working with Aster medical Centre, Aster DM Health Care Group, UAE. My area of interest is more into clinical cardiology, Assist Devices for Heart failure, heart transplant, stem cell research in end stage cardiac disease patients. He had presented papers in both national and international conferences, and I have publications In SCAI, Society of Cardiovascular Angiography and Interventions, USA, official publication, journal of Catheterization and Cardiac Interventions (CCI) and also presented papers in ASIA PCR/SINGAPORE LIVE in January 2014.

Abstract: Should every abandoned pacemaker lead be extracted during lead revison? Will abandoned pacemaker leads harbor the risk of life threatening arrhythmias? – An interesting case report of unsuccessful explantation with abandoned lead causing VT and VF and cardiac arrest that necessitated the implantation of ICD. Transvenous pacing has become widespread since past two decades. The improved reliability and assured longevity justify pacing in life threatening conditions. Some of these implantations will require the pacing leads or pulse generators to be revised or explanted because of high threshold of leads or up gradation or repair procedures during a long period of time. Here we report a case report of failed explantation with abandoned pace maker lead that caused recurrent VT and VF and cardiac arrest in a patient finally necessitated the implantation of ICD. This 55 year old male, a known case of hypertension and Complete Heart Block (CHB), for which permanent pace maker implantation (PPI) implantation has been done in 2003. Later due to lead problem because of high threshold, the original lead was abandoned and another lead was placed in 2011. He was doing fine and regular pace maker interrogations were normal. In 2013, he was admitted with pain abdomen, vomiting and abdominal distension, and he was diagnosed as a case of sub acute intestinal obstruction (SAIO), due to adhesions of pseudo pancreatic cyst. He was admitted under general surgery for the same, and he was surgically managed. Post surgery he was doing well except he had episodes of recurrent VT for which he needed DC shock. He also had suffered cardiac arrest, for which he was ventilated, and managed with ionotropes. Pace maker interrogation was normal. All the evaluation and metabolic parameters were within normal limits including electrolytes. The cause of VT was suspected as ischemia for which he was subjected for Coronary angiogram which showed normal coronaries. We finally concluded that the cause of VT could be due to irritating abandoned lead, and it was tried to pull out but we could not succeed. In view of recurrent episodes of VT, he was planned for ICD implantation and it was done. After implantation of ICD no further episodes of VT were reported. He is on regular follow up and no further symptoms were reported. This case reminds that the abandoned pace maker leads can give trouble in due course. Lead migration of abandoned pacing leads is rare complication resulting from improper securing of the cut end at its entrance site. In most cases, simple traction would be sufficient. However sometimes several extraction tools may be required in difficult cases and it is necessary to be performed by experienced hands to prevent complications.