Biography: Dr. Nassar is an assistant professor in the Department of Chemical and Petroleum Engineering at the University of Calgary, Alberta Canada. His research has covered various aspects of the processing, simulation and characterization of numerous types of metal-based nanoparticles. His main research interests are in the areas of nanotechnology and its applications in oil and gas industry, such as enhanced heavy oil upgrading and recovery, inhibition of asphaltene formation damage, asphaltene gasification, oil spillage remediation, produced and wastewater treatment, as well as air pollution control and polymeric nanocomposites. Dr. Nassar has trained around 25 graduate students and researchers. He published over 60 peer-reviewed publications and made over 50 technical presentations. He co-edited one book and obtained one United States patent. In addition to his excellent research activities, Dr. Nassar has outstanding teaching records as he is an expert in chemical, environmental and oil & gas engineering education, especially in process development and economy, separation processes, process design, effluent treatment processes, and natural gas processing technologies. Dr. Nassar has taught more than twenty five(25) different courses; at the graduate and undergraduate levels. In addition, Dr. Nassar has instructed and developed a number of workshops and short courses for new engineering graduates, technologists and professionals with different engineering background. Dr. Nassar is acting as the expert reviewer of several grant proposals and prestigious peer reviewed professional journals with high impact factor in the field of environment and energy; including Energy & Fuels, Industrial & Engineering Chemistry Research, Journal of Colloid and Interface Science, Nanotechnology, Science of the Total Environment, Fuel Processing Technology, etc. Dr. Nassar is a professional member of APEGA, and he strongly believes that the health of our environment and the development of our technology go hand-in-hand.
Abstract: Nanoparticle technology is a promising field of interdisciplinary research, which opens up numerous opportunities in various fields in the energy and the environment. Hence, potential uses and benefits of such technology are enormous. Our Nanotechnology Research Group at the University of Calgary has carried out a number of research activities pertaining to the synthesis and direct application of metal-based nanoparticles for enhanced oil upgrading and recovery, wastewater treatment, and H2S and CO2 capture. Methods for the application of nanoparticle technology in heavy oil processing can be conveniently categorized as in-situ and ex-situ application. In the in-situ application, resembles the in-situ upgrading and recovery of heavy oil in reservoir, whereby nanoparticles are directly exposed to real heavy oil feed. In the ex-situ part, resembles the on surface upgrading, nanoparticles are incorporated and dispersed into support and consequently used in a packed-bed process using real heavy oil feed. In both cases, the presence of nanoparticles significantly enhanced the upgrading and recovery of heavy oil. For convectional oil recovery enhancement, nanoparticles could decrease the interfacial tension (IFT) and increase the contact area through the reservoir by improving of sweep efficiency. Other mechanisms by which nanoparticles improve the EOR performance include alteration of rock wettability, changes in permeability and reduction in oil viscosity and mobility ratio. In addition, adding nanoparticles to injecting fluid can also prevent formation damage as nanoparticles may serve as inhibitors for asphaltene precipitation. As for wastewater treatment, nanoparticles functionalized with a petroleum vacuum residue (VR) could be used successfully for removing oil from oil–saltwater emulsions at different ranges of pH values. As for H2S and CO2 capture, metal-based nanoparticles could capture sulphur and CO2 and convert them into a chemically inactive mineral within the oil reservoir during the upgrading and/or recovery processes.
In this talk, we will show the recent findings obtained by our group pertaining to the use of in-house prepared metal-based nanoparticles for enhancing oil upgrading and recovery, wastewater remediation andH2S and CO2 capture. We believe our work in synthesis and application of nanoparticles will provideviable alternate clean technologies for enhancing oil recovery, wastewater treatment and CO2 capture.
Biography: Axel Lorke received his PhD in Experimental Physics in 1991 from
the Ludwig-Maximilians-Universität (LMU) Munich. He worked as a
PostDoc at the University of Tokyo, the University of California,
Santa Barbara, and the LMU Munich. In 2000 he was appointed full
professor for Experimental Physics at the University of Duisburg-
Essen. His work focuses on the electronic and optical properties nanostructures
and low-dimensional semiconductors. From 2004 to 2010
he was the coordinator of the Collaborative Research Centre
‘Nanoparticles from the Gas Phase’. He is co-founder of the ‘Center
for NanoIntegration Duisburg-Essen’ (CENIDE), and presently
spokesperson of the Interdisciplinary Center for Analytics on the
Nanoscale. Lorke is author and co-author of 6 patents and more than
160 refereed publications with a total of 5500 citations.
Abstract: Providing our society with clean and affordable energy has become one of the most important
challenge of our times. In the past few years, the use of nanomaterials for energy-relevant technologies
has become a topic of rapidly increasing interest. On the one hand, this is because nanostructured matter
offers a route to novel materials, tailored to exhibit specific properties. On the other hand, nanoscale
systems have a huge surface-to-volume ratio - and many energy-relevant processes take place at surfaces
and interfaces (friction, charge transfer and storage, light-energy conversion, etc.). Some major challenges
that need to be overcome in order to use nanotechnology in energy-relevant technologies are the
production of sufficient amounts of material, a thorough understanding of the basic properties, and the
integration into technologically relevant structures.
In this talk, these topics will be addressed in the context of a few examples, which show the
potential of nanomaterials in energy technologies. In particular, the use of nanoparticles from the
gasphase will be discussed. Select topics will include thermoelectrics, photovoltaics, solid-state lighting,
and battery technologies.
Biography: Dr. Udo Schwingenschlögl is a Professor of Materials Science & Engineering at King Abdullah University of Science and Technology (KAUST), Saudi Arabia. He previously worked at the International Center of Condensed Matter Physics in Brasilia, Brazil, and the Universität Augsburg in Germany.
Abstract: We discuss recent developments in the field of first-principles calculations addressing the structural and electronic properties of two-dimensional (2D) materials. The focus of the first part of the talk will be on silicene, the Si analogue of graphene, which is of great present interest due to its compatibility with the established Si technology. In particular, the effects of the substrate and strategies for achieving a quasi-freestanding configuration are addressed.Layered transition metal dichalcogenides have shown the potential to achieve 2Dmaterials applying routes based on specific growth techniques or resembling the exfoliation of graphene from graphite. The talk will focus on prototypical monolayer MoS2 to obtain insight into the influence of defects and substitutional doping on the material properties, for a wide range of transition metal dopants. Polar monolayers will be studied with respect to both their structural stability and the consequences of strong spin-orbit coupling. Strain is one of the most efficient tools to engineer to properties of monolayer transition metal dichalcogenides, though unexpected effects can be encountered. As an example,huge valley drifts off the corners of the Brillouin zone (K points) will be demonstrate for uniaxial strain, more than an order of magnitude larger than in graphene. In the context of the emerging field of valleytronics, the dependence of the valley polarization on the interplay between the spin-orbit coupling and the exchange interaction will be discussed.
Biography: Magnus Willander, who is a professor in Linköping University, Sweden and in Chinese Academy of Science, Beijing, BINN, is and has been active in the fundamental and applied research in physics and chemistry. In these areas he has published around 1000 scientific articles. He has done several pioneering works on semiconductor and polymer devices and in nanotechnology.
Abstract: I will present recent results from us regarding growth, characterization and applications of different semiconducting and polymer nanostructures and nanocomposites. I will illustrate their potential applications on some different electrochemical applications such as chemical sensors, photodegradations of dyes, antibacterial applications, and different energy harvesting applications. I will do this for the nanostructures and nanocomposites on both flexible and solid substrates.
Biography: Dr. Anwar is currently working on (a) ZnO Nanowire based UV detection and energy harvesting, (b) III-Nitrides and Oxide Semiconductor -based high power and high temperature quantum cascade lasers and (c) RF Oxide Semiconductor and III-Nitride HFETs and (d) memristors, to name a few. Dr. Anwar’s team pioneered the design of low noise antimony-based-compound-semiconductor (ABCS) HEMTs with quaternary buffer/barrier and ternary, with a measured fT around 200FGHz and Fmin of 0.82dB at 15GHz. He has presented over 40 plenary and invited talks at national/international conferences, published over 240 archival journal publications, conference proceedings and book chapters and edited 9 volumes. Dr. Anwar serves as an Editor of IEEE JEDS and served as an Editor of the IEEE Transactions on Electron Devices (2001 – 2010) and serves as the conference chair of the international conference on Terahertz Physics, Devices and Systems, at SPIE Defense, Security and Sensing (2009-2015). Dr. Anwar is an SPIE Fellow
Biography: Prof. Giorgio Sberveglieri received his degree in Physics cum laude from the University of Parma (Italy), where hestarted in 1971 his research activities on the preparation ofsemiconducting thin film solar cells.
He is currently Director of the CNR –INO Brescia Section and SENSOR Laboratory at Brescia University( http://sensor.ing.unibs.it )where are working in the permanent staff more than 20 Researchers. Heis also the Deputy Director of the Department of Information Engineeringin University of Brescia.
In 1988 he established the Sensor Lab, mainly devoted to the preparationand characterization of chemical sensors based on nanostrucured metaloxide semiconductors either in form of thin film or more recently asnanowires and nanobelts. Furthermore, since the mid 90s, the lab isfocusing on the area of Electronic Noses for security, food andenvironmental applications.
In 1994, he was appointed full Professor in Experimental Physics. He isreferee of many international journals and has acted as Chairman in several Conferences onMaterials Science and on Sensors. He has been the General Chairman ofIMCS11th (11th International Meeting on Chemical Sensors) and of the EUROSENSORS 2014 Conference.
He published about 470 papers, including 5 cover papers, getting over 7700 citations and an h-index of 45.
Abstract: After the first method proposed for the preparation of metal oxide in forms of nanobelts, plenty of literature was devoted to different experimental techniques that may lead to the formation of these quasi one-dimensional structures. At the beginning, the research was focusing on the vapour phase methods that were producing, with cheap instrumentation, high quality nanostructures in terms of crystallinity and stoichiometry. We have thoroughly studied the synthesis using evaporation and condensation from powder in controlled environment using different experimental set up. Metal oxide nanowires were integrated in our lab in functional devices for chemical sensing and then tested towards a wide range of chemicals, including odorous molecules and Warfare Agents.
The ability to prepare metal oxide in form of single crystalline nanowire has pushed further the research on this topic especially for the integration in functional devices such as chemical and gas sensors. There is still a lot of work going on regarding the preparation of oxides, like controlling their morphology and position at the nanoscale level. A big issue concerning the development of sensors is their reliable integration on the specific transducers, assuring stable electrical contacts over long-term operation. The ability to prepare stable single crystal quasi one-dimensional metal oxide nanostructures is having an impact on different aspects of science and technology. In particular, their integration in gas sensing devices lead to a significant improvement in stability providing stable and reliable electrical contacts. Furthermore, the possible miniaturization of these devices may produce a strong decrease in power consumption, the use of self heating devices allow the sensing even without the presence of a heater on the transducers.
Combining experimental and simulations techniques in a multidisciplinary and complementary approach, will result in a maximization of the understanding and therefore in the preparation of reliable chemical sensing devices for diverse applications like food safety, security and environment monitoring
Biography: Prof.Dr.A.Abdelghani is a Full Professor at the National Institute of Applied Science and Technology (INSAT, Tunisia) working mainly in the field of Microsensors and Microsystems. He obtained the master degrees in "Microelectronic Devices" at the INSA of Lyon (France) in 1994, then a Ph.D thesis from Ecole Centrale of Lyon (France) in 1997. He obtained a post-doc position in Germany between 1997-2000. He obtained the Habilitation in Physics in Tunisia (faculty of Science of Tunis) in 2004 and a Habilitation (worlwide recognition for conducting and leading research) in "Sciences pour l’Ingénieur" in 2009 at the Ecole Normale Supérieur de Cachan (France). He organized three International Conferences in Tunisia in the Field of Nanotechnology (2009, 2012 and 2014) with the Alexander Von Humboldt Foundation (Germany). He is now the leader and principal investigator of a research group working mainly on gas sensors based on functionalized carbon nanotubes (metallic oxides, nanowires, nanoneedles, polymers) and on the development of interdigitated gold microelectrodes integrated in microfluidic cell for bacteria analysis in biologic medium. He published more than 85 papers in International Journals and supervised more than 10 Ph.D thesis and 30 masters student. Prof. Abdelghani is part of worldwide renowned scientists as editorial member of several peer-reviewed scientific journals. He was a coordinator of Science For Peace NATO Project (2009-2011), National science Fondation Project (2009-2013), of Tempus-Project (2013-2016) and coordinator of a recent NATO-SFP project (2013-2016). He is deeply involved in industrial applications in his field of research with implications for the design and the development of affordable and cost-effective sensing devices for diagnostics and theranostics which will have an effective impact in the developing countries.
Abstract: C-reactive protein (CRP) is a protein present in plasma and is one of the most expressed proteins in acute phase inflammation cases, being a known biomarker of inflammatory states. Detection and quantification of CRP in an easy, cheap, and fast way can improve clinical diagnostics in order to prevent serious inflammatory states.
In this work, we study the electrochemical and optical properties of protein G layer grafted on gold microelectrodes with impedance spectroscopy and surface plasmon resonance imaging techniques for C-reactive protein detection. Two CRP-antibody immobilization methods were used: the first method is based on direct physisorption of CRP-Antibody onto gold microelectrodes; the second one is based on oriented CRP-antibody with protein G intermediate layer. The two developed immunosensors were tested in presence of CRP antigen in phosphate buffer saline solution with impedance spectroscopy and surface plasmon resonance imaging The reproducibility was tested against five substrates prepared in the same conditions at room temperature. The negative control was obtained after different injection of antigen-rabbit onto gold microelectrode coated only with anti-CRP antibody.
Biography: Nekane Guarrotxena Ph.D. from the University of Complutense, Madrid-Spain in 1994 and has been post-doctoral research at the EcoleNationaleSuperieured´Arts et Metiers, Paris-France (1994-1995) and the University of ScienceII, Montpellier-France (1995-1997). From 2008-2011, she was visiting professor in the Department of Chemistry, Biochemistry and Materials at University of California, Santa Barbara-USA and the CaSTL at University of California, Irvine-USA. She is currently Research Scientist at the Institute of Polymers Science and Technology, CSIC-Spain. Her research interest focuses on the synthesis and assembly of hybrid nanomaterials, nanoplasmonics, and their uses in nanobiotechnology applications (bioimaging, drug delivery, therapy and biosensing).
Abstract: Rational assembly of nanoparticles (NPs) is relevant for effective exploitation of structure-dependent material properties and for making nanostructured materials with specific activity in optical (sensing) and electronic (nanodevices) applications. Despite relevant improvements on solid surfaces, fabrication and organization of narrow size- and shape distributions of NPs in solution remain a challenge. One of the most successful approaches for their fabrication involves use of colloids and well-established thiolate adsorption chemistry. The general difficulty in this controlling aggregation methodology is that, the linking process is random by nature and is difficult to control, generating a statistical distribution of aggregated NPs. An alternative to non-ideal NPs assembly would be an effective postsynthetic purification method. In this presentation, we will focus on this approach for collecting efficient and intense optical SERS active nanostructure for novel applications fromNP-assemblies pool.
Biography: Dr. Nicholas Adkins is a Senior Research Fellow in the Advanced Materials & Processing Laboratory at the University of Birmingham, UK. Having received his PhD in Metallurgy in 1986 from the University of Surrey he has over 30 years experience in Powder Metallurgy and the application of Hot Isostatic Pressing. Nick now works at the University on several large, EU-funded, projects including “AMAZE”, the largest EU project on Additive Manufacturing, “AccMet” a large programme on combinatorial metallurgy and “Exomet” on metal matrix nano-composites. He is co-author of over 60 publications and 6 patents
Abstract: Development of high performance light alloys is key for the aerospace and automotive industries. This paper introduces a way to increase the properties of current alloys by introduction of nanomaterials into the metal matrix. Industrial scale application of metal matrix composites (MMC) is usually limited by the complexity of MMC production and the scalability of the manufacturing process. A novel method of production of master alloys has recently been developed at the University of Birmingham. This method includes fabrication of porous media from nanomaterial (preform) andfurther infiltrationof preform with the liquid metal. Magnesium master alloys with the loading from 15vol% to 30vol% of SiC nanomaterial have been produced. The method of production of the preform using starch consolidation is described. Hot Isostatic Pressing (HIP) of a specially designed mild steel container has been used to infiltrate the preform. The high pressure available during HIP process (up to 150MPa) ensures infiltration of the magnesium alloy to full density. The preform is at the same temperature as the metal during infiltration.
The master alloy could be diluted during convention melting process to produce a nanocomposite with 2% loading. Some preliminary mechanical properties for the composite are presented.
This work was undertaken as a part of the European Community funded FP7 research project ExoMet “Physical Processing of Molten Light Alloys under the Influence of External Fields”.
Biography: Professor Siegfried Selberherr was born in Klosterneuburg, Austria, in 1955. He received the degree of Diplomingenieur in electrical engineering and the doctoral degree in technical sciences from the Technische Universität Wien in 1978 and 1981, respectively. Dr. Selberherr has been holding the venia docendi on computer-aided design since 1984. Since 1988 he has been the Chair Professor of the Institut für Mikroelektronik. From 1998 to 2005 he served as Dean of the Fakultät für Elektrotechnik und Informationstechnik. Prof. Selberherr published more than 350 papers in journals and books, where more than 100 appeared in Transactions of the IEEE. He and his research teams achieved more than 1000 articles in conference proceedings of which more than 150 have been with an invited talk. Prof. Selberherr authored two books and co-edited more than 30 volumes, and he supervised, so far, more than 100 dissertations. His current research interests are modeling and simulation of problems for microelectronics engineering. Prof. Selberherr is a Fellow of the IEEE, a Fellow of the Academia Europaea, a Fellow of the European Academy of Science and Arts, and a Distinguished Lecturer of the IEEE Electron Devices Society.
Abstract: The breath-taking increase in performance of nanoelectronic circuits has been continuously supported by the
uninterrupted miniaturization of devices and interconnects. Among the most crucial technological changes lately
adopted by the semiconductor industry is the introduction of a new type of multi-gate three-dimensional (3D)
transistors . This technology combined with strain techniques and high-k dielectrics/metal gates offers great
performance and power saving advantages over the planar structures and allows continuing scaling down to
14nm feature size and beyond. In order to continue with scaling further, a new material with improved transport
characteristics for the channel must be introduced . Although single devices with gate length as short as a few
nanometers have been demonstrated , fabrication, control, and integration costs combined with reliability
issues will gradually bring conventional transistor scaling to an end.
The principle of transistor operation is fundamentally based on the charge of an electron interacting with the
gate voltage induced electrostatic field. Another intrinsic electron characteristic, the electron spin, attracts at
present much attention as a possible candidate for complementing or even replacing the charge degree of
freedom in future electronic devices. The electron spin state is characterized by two projections on an axis and
could be potentially used in digital information processing. In addition, it takes an amazingly small amount of
energy to invert the spin orientation. The key advantages of all spin-based computing as compared to a
conventional processor with equivalent functions are zero static power, small device count, and low supply
voltage, as listed in a recent review .
Silicon, the most important material of electronics, predominantly consists of nonmagnetic 28Si nuclei and is
characterized by weak spin-orbit interaction. Because of these properties the electron spin lifetime in silicon is
relatively long. This makes silicon a perfect candidate for spin-driven device applications. However, even a
demonstration of basic elements necessary for spin-related applications, such as spin injection, detection, and
propagation was missing until recently. The fundamental reason has been identified as an impedance mismatch
problem . Even though there is a large spin imbalance between the majority and minority spins in a metal
ferromagnet, both channels with spin-up and spin-down are equally populated in a semiconductor due to the
small density of states as compared to that for the minority spins in a ferromagnet. In other words, because of the
large resistance of the semiconductor, the voltage applied to the contact between the ferromagnet and the
semiconductor drops completely within the semiconductor, and the properties of the contact are dominated by
the non-magnetic semiconductor, thus resulting in a current without spin polarization. A solution to overcome
this problem is to use the hot electron injection ; however, the efficiency of spin injection and detection is
Another solution to the impedance mismatch problem is the introduction of a potential barrier between a metal
ferromagnet and a semiconductor . In this case the influx of carriers from the ferromagnet into the
semiconductor is reduced proportionally to the ration of the densities of states in a semiconductor and a
ferromagnet. This guarantees the spin injection into the semiconductor. A successful experimental proof of spin
injection at low temperature from an iron electrode through aluminium oxide  was demonstrated in 2007. At
room temperature spin injection into n- and p-doped silicon was shown in 2009 . The authors used heavily
doped silicon samples to avoid an extended depletion layer causing large tunnel barriers. The problem of making
good contacts with low resistance per area is critical for spin injection. Tunnel contacts made of a single layer
graphene  have been shown to be close to optimal . Electrical spin injection through silicon dioxide at
temperatures as high as 500K has also been demonstrated .
Regardless of an ultimate success in demonstrating spin injection into silicon at room temperature, there are
unsolved issues, which may compromise the present understanding of the spin injection process in general. One
problem is a several orders of magnitude discrepancy between the signal measured in a scheme where the same
ferromagnetic contact is used to inject and to measure the spin accumulation and its theoretical value .
Similar observations were also made for germanium  as well as for other semiconductors . These
discrepancies are heavily debated , ,  and more research is needed to resolve the controversies.
The excess spin is not a conserved quantity: While diffusing, it gradually relaxes to its equilibrium value which
is zero in a nonmagnetic semiconductor. Spin can propagate 350 microns through a silicon wafer at 77K . The
spin diffusion length in silicon at room temperature is around 200nm . In a confined electron structure the
spin lifetime is further reduced due to the additional spin relaxation at the interfaces . This shortens the spin
diffusion length further, which represents a threat for using CMOS transistors for spin-driven applications.
Technologies to boost the spin lifetime are needed.
The spin lifetime is determined by the spin-flip processes. Several important spin relaxation mechanisms are
identified [19, 20]. The Elliot-Yafet mechanism is mediated by electron-phonon interaction and the intrinsic
interaction between the orbital motion of an electron and its spin is responsible for the spin relaxation in silicon
. The main contribution to the spin relaxation is due to optical phonon scattering between the valleys
residing at different crystallographic axis, or f-phonon scattering . Stress lifts the degeneracy between the
non-equivalent valleys and can suppress the spin relaxation by a factor of three.
The theory of spin relaxation in inversion layers and thin films must account for the most relevant scattering
mechanisms, namely electron-phonon interaction and surface roughness scattering. It turns out that in (001)
silicon films, where the non-equivalent valley degeneracy is lifted by confinement, the spin lifetime is controlled
by the intervalley scattering processes between the equivalent valleys . This is in contrast to the effect on the
momentum relaxation time which is determined by the elastic intravalley scattering. Uniaxial stress along 
direction lifts the remaining degeneracy between the two equivalent valleys thus reducing the intervalley spin
relaxation . This results in a giant, close to two orders of magnitude, spin lifetime enhancement  at
saturation for shear strain values of about 1.5%. At the intermediate strain values the spin lifetime increase is
almost exponential. Strain techniques are now routinely used to boost the electron mobility. It is therefore
straightforward to apply the same techniques to obtain a spin lifetime close to 1ns required for spin-driven
applications in CMOS transistor technology.
For building a SpinFET  purely electrical spin manipulation in the channel is required. However, the channel
length required to rotate the spin substantially in silicon is several microns and thus too large . The only
viable option left to use nanoscale CMOS is likely to convert a MOSFET to a SpinFET by adding the spin
degree through introducing ferromagnetic source and drain contacts . The current in this structure depends
on the relative orientation of the magnetizations of source and drain paving the path towards programmable nonvolatile
logic. The contact magnetization direction can be switched electrically by using spin torque transfer.
However, due to the low spin injection efficiency at room temperature, a SpinFET has not yet been realized.
Although significant progress in understanding spin injection, transport, and detection in silicon has been
achieved, more research is urgently needed to increase the spin injection efficiency at room temperature and to
resolve the issue of spin manipulation by pure electrical means. The most viable option for practical spin-driven
applications in the near future is to use magnetic tunnel junctions (MTJs). MTJ-based spin transfer torque
MRAM is CMOS compatible, non-volatile, and scalable. It is fast and, in addition, characterized by an infinite
endurance and high density. 64Mb MRAM arrays are already in production. A combination of an MTJ with a
MOSFET opens a new opportunity to built non-conventional non-volatile logic-in-memory systems .
Biography: Dr Farah Benyettou explored the chemical processes for drug delivery and the synthesis and modification of commercial anti-cancer drugs from the Bisphosphonate family. Subsequently, shee developed new and innovative anticancer superparamagnetic nanoparticles for drug delivery from the synthesis, to the characterizations and the biological evaluations. Dr Benyettou’s research approach is to use complementary properties such as porosity and magnetism, and develop new multifunctional and smart nanoplatforms for simultaneously imaging and therapy.
Abstract: Cytotoxic drugs are used during cancer chemotherapy to inhibit tumor growth and metastasis. However, many chemotherapeutic drugs, such as doxorubicine (Dox), have limited cellular uptake and a strong tendency to bind to off-target macromolecules. Together these characteristics lead to low therapeutic indices. Increasing the intracellular uptake of cancer drugs could prevent these complications.
Another pitfall of chemotherapy is drug resistance. One strategy for avoiding drug resistance is drug combination. This approach can prevent side effects by allowing for reduced dosages and can improve efficacy if the chosen drugs act synergistically. For example, bisphosphonates act synergistically with many other anti-cancer agents. Alendronate (Ald), one of the most potent bisphosphonates, has been shown to increase cancer cell death in vitro when combined with Dox in breast cancer cells.
We present here the synthesis of a silver nanoparticle-based drug delivery system that improves the anticancer therapeutic indices of doxorubicin (Dox) using alendronate (Ald) as an adjuvent. Water, under microwave irradiation, was used as the sole reducing agent for the size-controlled, bisphosphonate-mediated preparation of silver nanoparticles (AgNPs). The AgNPs were coated with and stabilized by the bisphosphonate alendronate (Ald). The bisphosphonate group of Aldtemplated the formation of the AgNPs, and was the site of the drug’s attachment to the nanoparticles. The free primary ammonium group of Ald was subsequently functionalized with either Rhodamine B (RhB) by amide linker formation or Dox through imine bond formation. The RhB-conjugated nanoparticles (RhB-Ald@AgNPs) were studied in HeLa cell cultures. Confocal fluorescence microscopy studies determined the main mechanisms of cellular uptake of the nanoparticles. The imine linker of the Dox-modified nanoparticles had significantly greater anti-cancer activity in vitro than either Ald or Dox alone.
Thus, the ability of Ald to promote the assembly of Ald@AgNPs in a one step reaction, and the straightforward post-modification of Ald@AgNPs, offer an easy and environmentally friendly strategy for the formation of stable nanoparticles that couple the antiproliferative properties of the AgNPs, themselves, to those of the drug mixtures they carry. This system features a high degree of functionality and potency and is of potential therapeutic benefit
Biography: Mohamed Elblbesy Ph.D. Alexandria University, Alexandria - Egypt in 2005. He is assistant professor of Medical Biophysics in Medical Research Institute, Alexandria University, Egypt. He works now as associate professor in faculty of Applied Medical Science, University of Tabuk, Saudi Arabia. After studying physics as an undergraduate, He opted to follow a research career in the biophysical sciences. His PhD was initially in biophysical properties of blood and hemorheology. His work at Alexandria University initially revolved around analysis of the physical properties of red cells, and their effect on blood flow. He tried to understand red blood cells aggregation and electrical and magnetic properties of red blood cells in normal and abnormal states. As development of His work and knowledge He went toward nanotechnology. His research in nanotechnology focus on the study of the effect of the synthetic nanoparticles on the rheological properties of the blood specially the natural synthetic nanoparticles like albumin and chitosan nanoparticles
Abstract: Nanoparticles are colloidal particles, which are less than 1 µm in diameter. They have the unique property to accumulate at the site of inflammation and therefore, are very suitable for targeted drug delivery. As a major plasma protein, albumin has a distinct edge over other materials for nanoparticles preparation. It is cheap and easily available. The present work was aimed to prepare bovine albumin nanoparticles (BAN) with simple coacervation method and test their hemocompatibility. Albumin nanoparticles obtained by this method were in size range 250-350 nm at pH= 7.4 with. In vitro hemocompatibility tests of the prepared (BAN) had been done after incubation of BAN with normal blood for two hours at 37°C. Hemocompatibility tests showed that reduction of hemolysis percentage of erythrocytes due to exposure to BAN. The other blood parameters such as hemoglobin (HG), mean corpuscle hemoglobin (MCH), mean corpuscle hemoglobin concentration (MCHC) were in the normal. Prothrombin time (PT) and erythrocytes sedimentation rate (ESR) decreased as the concentration of BAN increase. Due to the results obtained in this study it was proven that BAN could be used safely and without abnormal effect when interacted with blood through many biomedical applications.
Biography: Dr. Hassan A. Hemeg pursued Masters in Pathological Science from Sheffield University, UK and received his Ph.D. fromKing Abdulaziz University, Saudi Arabia. He also completed Diploma in National Association of Safety Professionals from USA. He has earned several honors such as Fellow of the Institute of Biomedical Science, UK andCertified Canadian Accreditation Specialist for Health Care Facilities. He also acquired training in Microbiology from SheffieldUniversity and Bristol University, UK and,U.S Department of Labor Occupational Safety and Health Administration. He has also worked asEducational Instructor and Supervisor in Clinical Molecular Microbiology Laboratories at King Abdulaziz University Hospital, Jeddah and as Head of Environmental Health and Safety Unit at King Abdulaziz University Hospital.He has served as a member, Secretary and Chairman of several Committees and is a permanent representative of Ministry of Higher Education in Safety Traffic Committee. Presently, he is also the Vice Dean of Medical Applied Science College at Taibah University. Hisresearch interest is antimicrobial. He has published several papers in Journals of International repute.
Abstract: Despite numerous potent antibiotics, bacterial infections, particularly those caused by nocosomial pathogens are a major cause ofmorbidityand mortality around the globe.These affect the severely ill, hospitalized and immunocompromised patients who are vulnerable to infections. The option for treatment with antimicrobials is mostly empirical and not bereft of toxicity, teratogenicity and/ormutagenicity, hypersensitivity. The appearance of multi-drug resistant bacterial strains further aggravates the clinical problem as the microorganisms spread epidemically among the patients. Moreover, there is a growing concernregarding biofilm-associated infections that are refractoryto the currently available antimicrobial armory, leaving almost no treatment option. Thus, there is an urgent need to develop additional bactericidal agents.The attention has been especially devoted to new and emerging nanoparticle-based materials in the field of antimicrobial chemotherapy.
The past decade has witnessed a substantial surge in the global use of nanomedicines as antimicrobials. Several metal and metal oxide nanoparticles have been reported for their antibacterial activity. The microbes are eradicated either by the microbicidal effects of the nanoparticlesitself, or by microbistatic effects followed by killing potentiated by the host's immune system. Theeffect of nanoparticles on the microbial biofilms along with the molecular mechanisms by which the nanoparticles annihilate multidrug-resistant bacteriawill be discussed. Combinatorial therapeutic approach with the metallic nanoparticles may serve as adjunct to the existing antibiotics and may help to curb the mounting menace of bacterial resistance and nocosomial threat.
Biography: Prof. Dr Najoua-Turki Kamoun is a full Professor at the Faculty of Sciences of Tunis (FST)/
University of Tunis El-Manar Tunisia. She obtained her Ph.D thesis in 1992 from FST and
the Habilitation in Physics in Tunisia (FST) in 2000 and she is a Professor since 2007. Her
academic research focuses on Transparent conductive oxides (TCO: ZnO, SnO2, In2O3,TiO2), binary semiconductors ( In2S3, SnS, CdS, Cu2S, ZnS, PbS), ternary (CuInS2, In(2-x)GaxS2, P3HT) and quaternary compounds(CuIn(1-x)GaxS2:CIGS and Cu2ZnSnS4:CZTS) for optoelectronic applications such as photocatalysis, gaz sensors, solar cells, UV and IR detectors. Nanomaterials and thin films are grown by different low cost techniques (spray pysolysis, chemical bath deposition, spin coating). She published more than 90 papers in International Journals and supervised more than 20 Ph.D thesis.
Since 1989 she is a researcher in Physics Condensed Matter Laboratory (LPMC) where she is
a head since 2011. In the period 2013-2014 she occupied the post of General Director of
Physico-Chemical Analysis Institute in the Technopole of Sidi Thabet
Abstract: We have studied the effect of the flow rate on the physical properties of CuInS2 thin films. But as the indium is anexpensive element and rare in the earth’s crust, CuInS2 is replaced by Cu2ZnSnS4 (CZTS) which has received considerable attention as one of the promising absorbers for the fabrication of solar cells with conversion efficiency close to 12.6%.
In order to improve its structural, morphological, electrical and optical properties, we started by preparing CZTS thin film using an aqueous solution at various substrate temperatures by spray pyrolysis technique. Next Sprayed CZTS thin film prepared under the optimised conditions is annealed in nitrogen atmosphere at 450, 500 and 550 °C during 60 min.
In another hand, we have prepared the CZTS thin films using an ethanolic solution atvarious sulfur concentration then the film deposited at the optimised condition was annealed under nitrogen atmosphere for an hour at different annealing temperatures.
Finally, as ultimate test it is useful to finish some solar cells and test them accordingly. In our next researches, we can test our findings through the proposed following solar cell: Ag/CZTS/CdS/ZnO/ZnO:Al. The CZTS thin films will be elaborated under the optimized experimental spray parameters for both solution types.
In our laboratory, cadmium sulfide nanomaterial is grown by Chemical bath deposition it is a buffer layer and Zinc oxide material is synthetised by spray pyrolysis it is an optical window in solar cell devices.
Biography: Alicja Porenczuk (born 21-03-1986, Torun, Poland), is a graduate from the Warsaw Medical University in Poland (D.D.S degree in 2010 and PhD in 2015). She is also a trained specialist in restorative dentistry and endodontics. She lives and works in Warsaw. Her scientific studies focus on the laboratory assessment of metal nanoparticles’ features and their influence on dental materials, especially resin adhesives. She is the author of 6 articles on nanomaterials, ex. shear bond strength, antibacterial properties, and is planning to widen the range of research in the future. As a private person, she is happily married, loves dancing and yachting.
Abstract: Dental caries is the most frequent oral disease worldwide. Due to the restorative materials’ technical imperfections and procedural mistakes, more than half of the cavity restorations are replaced due to bacterial microleakage. Therefore, the need for disinfection agents, such as silver nanoparticles (AgNPs), arises. The aim was to assess the shear bond strength (SBS) to dentin and failure modes of different dental materials (total-etch bonding system OptiBond Solo Plus® (Kerr Italia S.r.l. Scafati, Salerno, Italy), self-etch bonding system Clearfil SE Bond® (Kuraray Noritake Dental Inc., Kurashiki, Okayama, Japan), glass-ionomer cement Ketac Molar EasyMix® (3M ESPE Dental Products, St. Paul, USA)) following AgNPs (Nanocare Gold®; Dental Nanotechnology Ltd., Katowice, Poland) application. Forty-two non-carious extracted human third molars were chosen for the study comprising the SBS test followed by thermocycling of the probes used for an artificial ageing of the fillings, SEM/FIB, SEM/EDX and endodontic microscope evaluations. The AgNPs (shape mainly spherical of mean size 48 nm; concentration 3.96 µg/µl) in the material are attached to a liquid (isopropyl alcohol) and solid carriers. The results showed no impact of AgNPs addition to dental materials in terms of SBS to dentin. A change of the failure mode of the self-etch bonding system combined with AgNPs was observed, which may have a serious clinical impact. Also, the AgNPs were seen to be gathered in larger agglomerations in the dentin-adhesive border zone.
Biography: Sondes Machat obtained her Engineer diploma from the « Ecole Supérieure Privée d'Ingénierie et de Technologie » Tunisia in June 2014. She has a good experience in telecommunications, computing, maintaining websites, and management of administrative details of running a high-level conference meeting and workshops. She is now working on developping new ideas of start-up, business plan and implementation of nanotechnology in developing countries.
Abstract: In this work we present an approach for the use of devices for analyte (pesticides, bacteria, heavy ions, C-Reactive Protein, etc..) detection for different applications (food analysis, water anaylsis, medical diagnostic, etc..). Most of the analyte detection systems used in vivo are time consuming and need different steps of preparation (labeling, etc..) and which are currently used for diagnosis in intensive care units and Hospitals. The development of new device need laboratory experiment for stability, rabidity and reproducibility studies. We will show the need of the market for such kind of devices and namely for developing countries.
Abstract: Revealing structure-property relationship has been one of the key issues for development of novel functional or high-performance polymeric materials. We recently keep attention at “grain” of block copolymer microdomains because the grain of which size is several micrometers is considered to affect properties more directly. In this presentation, we focus on a grain in which spherical microdomains of block copolymers are regularly ordered in body-centered cubic (BCC) lattice. Especially, we discuss growth of the grain on a free surface of a thin film where (110) planes of the BCC lattice are spontaneously oriented parallel to the film surface. The sample used is PS-block-PEB-block-PS (SEBS8) triblock copolymer (PS (polystyrene) spherical microdomains embedded in the matrix of PEB (polyethylenebutylene); Mn = 6.7 104, Mw/Mn = 1.04, PS = 0.084 (volume fraction of PS). The sample was spin-cast on a silicon wafer from a toluene solution with a polymer concentration of 5.0 wt% at room temperature. Then, the as-spin-cast film was further subjected to the thermal annealing at 140˚C under the nitrogen atmosphere. The surface morphology was analyzed by atomic force microscopy (AFM), using apparatus Nano Scope IIIa with a cantilever (NANO WORLD) of which length was 125 mm and the spring constant was 42 N/m. The AFM observation was conducted with tapping mode by using J-Scanner (5654V).
Abstract: Heterostructure core-shell nanomaterials photoconductors tend to exhibit high photoconductive gains and long recovery times mainly due to surface effects.We report the growth of CuO/CdSe core-shell heterostructures nanowires(NWs) synthesized by combining thermal oxidation deposition and chemical vapour deposition technique. Characterization of materials by scanning electron microscope, x-ray diffraction and and transmission microscope reveals the formation of highly dense crystalline semi-aligned CuO/CdSe core-shell heterostructure nanowires. The CuO/CdSe core/shell hetero structure NWs were then used as the active medium to fabricate a photo detector device. The CuO/CdSe core-shell heterostructure NWs as a photoelectrode with responsivity 10 A/W which corresponds to an external quantum efficiency of approximately 49 % have been obtained. The achieved high responsivity in the CuO/CdSe core-shell heterostructure NWs can mainly be attributed to the abrupt nature of the interface between CuO and CdSe, which effectively inhibits carrier recombination and facilitates an efficient carrier separation. Under illumination, the electron of CuO and CdSe present in their respective valence band are excited and move to their respective conduction band giving rise to current. The photo-generated electrons in the conduction band of CdSe are injected to the conduction band of CuO, leading to the high electron concentration in the conduction band of CuO. Due to the high carrier mobility, the high-crystalline CuO core makes it an effective channel for conducting electrons, while the holes are transported through CdSe. The separation of the charge carriers minimizes their recombination rate that results in increasing the photocurrent. These results demonstrate that the prepared heterostructured NWs can indeed serve as high performance photodetectors in the UV-Vis range